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  • Evidence is increasing that all addiction without exception is related to issues with the brain's reward center, especially the mesolimbic system. This part of the problem regulates reward responses in establishing food and sex, along with nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both whenever they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008).

    Using two separate drugs to lose weight naturally can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the people who go through it you should err assisting caution and allow the FDA do its job and demand some investigation be done so the public understands the side effects and risks of the medications before we bring them. Keep in mind that drug companies have been in business to generate income and that they would say anything to keep people on the medications.

    Researchers discovered that participants taking this drug for a year, lost excess weight within a month and have kept the weight off through the 56 weeks from the study. Contrave is often a combination from the drugs naltrexone and bupropion, which appears to reflect a fresh trend of weight-loss drugs which are made up of multiple active ingredient, which can make them more efficient and safer.

    Combo-pilling is the newest fad or even better the newest in the future under scrutiny and therefore it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular is the fact that by right now there aren't long term prescription weightloss pills that have been authorized by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations happen to be rejected or have yet to be licensed by the FDA.

    Seizures really are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug may also raise blood pressure and pulse rate, and must not be used in people with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug.

    The FDA also warned that Contrave can raise blood pressure level and pulse rate and must stop used in patients with uncontrolled high blood pressure, along with by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients having a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients to the increased risk of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.

    The most common side effects reported with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.